AN UNBIASED VIEW OF FENTANYL FOR SURGERY

If coadministration of CYP3A4 inhibitors with fentanyl is essential, keep track of patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose changes till stable drug effects are achieved.lumacaftor/ivacaftor will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.